Semaglutide powder

1. What is Semaglutide  powder?

This kind of peptide is a polypeptide hormone composed of 14 amino acids. It is produced by pancreatic islet cells and neurons in the human body and is distributed in multiple tissues and organs. It works primarily by binding to specific receptors.

This peptide plays an important role in regulating various physiological processes. It inhibits gastric acid secretion, gastrointestinal motility, and the release of various endocrine hormones, thereby participating in regulating gastrointestinal function and insulin secretion. In addition, it has anti-growth, anti-inflammatory and immunomodulatory effects.

2. Certificate of Analysis

Certificate of Analysis
Product Name	Semaglutide	CAS NO.	910463-68-2
Salt Type	Na+	Manufacturing Date	2023.04.22
Sequence	His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEE γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH
Storage	Stable at 2-8℃,but should be kept at-20℃ for long term storage,preferably desiccated.
ITEM	SPECIFICATION	RESULTS
Appearance	White or off-white powder	Conforms
Solubility	Soluble in H2O	Conforms
Amino acid analysis	His (0.9-1.1) Asp(0.9-1.1) Ala(2.7-3.3) Val(1.8-2.2) Glu(4.5-5.5) Leu(1.8-2.2) Gly(3.6-4.4) Lys(0.9-1.1) Thr(1.8-2.2) Phe(1.8-2.2) Arg(1.8-2.2) Ser(2.7-3.3) Ile(0.9-1.1) Tyr(0.9-1.1) Aib(0.8-1.2) AEEA(1.6-2.4) Trp(Det)	His 1.0 Asp 1.0 Ala 3.2 Val 3.2 Glu 5.2 Leu 2.0 Gly 4.2 Lys 1.0 Thr 2.0 Ile 1.1 Phe 1.9 Arg 2.1 Ser 2.8 Tyr 1.1 Aib 1.0 AEEA 2.0 Trp(Det)
Purity	≥98.0%	99.29%
Mass Spectrum	4113.58±1.0	4113.8
Clear and color of solution	Clear and colorless	Conforms
Water	≤8.0%	2.51%
Thifluoroacetate ion	≤0.1%	N.D
PH	6.0-9.0	6.94
Sodium ion	≤4.0%	1.19%
Phosphate ion	＜0.5%	N.D
Chloride ion	＜0.5%	N.D
Related Dubstances(HPLC)	Any indivial impurity:≤1.0% Total impurity:≤2.0%	0.30% 0.72%
Resiual solvents	Methanol:≤0.3% Isopropanol:≤0.5% Acetonitrile:≤0.041% Methylene chloride:≤0.088% N,N-Dimethylformamide:≤0.088% Tert-butyl methylether:≤0.5%	Methanol:N.D Isopropanol:0.001% Acetonitrile:≤0.025% Methylene chloride:N.D N,N-Dimethylformamide:0.005% Tert-butyl methylether:N.D
Peptide Assay	≥85.0%	95.58%
Bacterial endotoxin	＜10EU/mg	Conforms
Conclusion	The test results comply with the requirements of in-house specification.

3. What is the function of Semaglutide powder?

First. Semaglutide is commonly used for type 2 diabetes. It is a glucagon-like peptide-1 (GLP-1) receptor agonist. Its main functions include stimulating insulin secretion, inhibiting glucagon secretion, slowing gastric emptying, and also reducing body weight.

Second. Semaglutide can simulate the active GLP-1 produced in the human body and bind to the GLP-1 receptor on the surface of pancreatic beta cells, thereby causing the insulin storage granules to secrete more insulin. In addition, semaglutide can also inhibit the secretion of glucagon by pancreatic islet α cells and reduce blood sugar.

Third. Semaglutide can also delay the emptying of food in the gastrointestinal tract, allowing diabetic patients to have a better feeling of fullness, reduce appetite, and thereby lose weight.

Semaglutide is long-acting, can be used only once a week, and is convenient. The original preparations needed to be injected into the body through subcutaneous injection, but in recent years oral preparations have been developed, which has greatly changed the treatment method, because oral administration can reduce the trauma of administration and greatly improve administration compliance and Convenience.

However, semaglutide is not suitable for everyone.  Use with caution in patients with severe liver,  kidney,  or gastrointestinal disease. Also, when you first start using semaglutide, work with your doctor to monitor your blood sugar levels to make sure this medication is working properly.

4. Application：

Semaglutide is mainly used for the treatment of type 2 diabetes and long-term weight management. As a glucagon-like peptide-1 (GLP-1) receptor agonist, semaglutide has the following main effects:

1.It reduces blood sugar levels by simulating the naturally occurring glucagon-like peptide-1 to enhance insulin secretion.

2.Inhibits the secretion of glucagon (also known as glucagon), a hormone that stimulates the liver to produce glucose when blood sugar is low.

3.Reduces gastric emptying, increasing the feeling of fullness and helping with weight loss by slowing the passage of food through the stomach.

In addition to injectable forms, semaglutide is also available in an oral form to facilitate patient needs. At the same time, this drug is also used for weight management in severely obese patients to reduce other health problems caused by excess weight.

However, semaglutide does need to be used rationally under the guidance of a doctor, because not all patients are suitable for treatment with semaglutide, especially for patients with severe liver disease, kidney disease, or gastrointestinal disease, and should be used with caution.

5.How to use the vials of Semaglutide?

Semaglutide is commonly used to control blood sugar levels in adults with type 2 diabetes and is used as follows:

1. Store medications in the refrigerator, do not freeze, and store unused new medication pens in the refrigerator in their original cartons.
2. When needed, inject semaglutide injection subcutaneously. According to medical advice, injections are generally administered once a week. If your doctor allows you, you can also use the newer oral formulations.
3. During the use of semaglutide, you must follow the doctor’s instructions and the medication instructions in the drug package insert, and strictly follow the dosage and frequency of use prescribed by the doctor.

If you miss a dose, make it up as soon as possible. However, if it is near the time of your next dose, you should skip the missed dose and return to your normal dosing schedule. Never double the dose. If you miss a dose by more than 5 days, skip the dose and return to your regular dosing schedule.

These are general medication recommendations. The specific medication method, dosage, and time should be based on your doctor’s instructions. When taking any new medication, you should discuss it with your doctor as soon as possible to understand its administration and possible side effects.

 

6. FAQ

1.What is the purity of Semaglutide ?

The purity is 99%.

2. What is the packaging?

This product is packed with vials, because it should be kept in sterile environment, it can have a good effect.

3. What is the  specification of the vials?

5mg/vial 10vials/box

10mg/vial 10vials/box

15mg/vial 10vials/box

4. How to contact us?

You can send email to liling@sunplantbio.com or add whatsapp +8618291416869